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目的观察重复经颅磁刺激(rTMS)对脑出血家兔血肿周围组织化合物含量的影响,并探讨其治疗机制。方法家兔36只,随机分为治疗组、模型组和对照组。治疗组和非治疗组采用兔自体血注射制作脑出血模型,对照组注射生理盐水。治疗组家兔于造模后12h开始实施rTMS,每日3次;模型组和对照组不进行rTMS。分别于造模后12h、3d、1周和2周,应用1H-磁共振波谱(1H-MRS)检测出血灶周围脑组织N-乙酰天门冬氨酸(NAA)、总肌酸(Cr)和胆碱复合物(Cho)等化合物的含量。结果与对照组比较,模型组和治疗组脑出血灶周组织内NAA和Cr含量减少,NAA/Cr降低,Cho含量增加,Cho/Cr增高(均P<0.01);与模型组比较,治疗组NAA、Cr含量增加,NAA/Cr增高,Cho含量减少,Cho/Cr降低(均P<0.01)。结论rTMS可通过促进血肿周围神经元的修复,影响脑组织中化合物含量,发挥神经保护性治疗作用。
Objective To observe the effect of repeated transcranial magnetic stimulation (rTMS) on the content of tissue compounds around the hematoma in rabbits with intracerebral hemorrhage and to explore its therapeutic mechanism. Methods Thirty-six rabbits were randomly divided into treatment group, model group and control group. The treatment group and the non-treatment group were injected with autologous blood of rabbits to make intracerebral hemorrhage model, and the control group were injected with saline. The rabbits in the treatment group were administered rTMS three times a day after model establishment 12h, while the model group and the control group were not rTMS. The levels of N-acetyl-aspartate (NAA), total creatine (Cr) and peroxisome proliferator-activated protein kinase (cTnA) in brain tissue were determined by 1 H-MRS at 12h, 3d, Choline complex (Cho) and other compounds content. Results Compared with the control group, NAA and Cr decreased, NAA / Cr decreased, Cho increased and Cho / Cr increased (all P <0.01) in the model group and the treatment group. Compared with the model group, NAA, Cr increased, NAA / Cr increased, Cho decreased, Cho / Cr decreased (all P <0.01). Conclusion rTMS can exert neuroprotective therapeutic effects by promoting the repair of neurons around the hematoma and influencing the content of compounds in brain tissue.