是 Jacobson 和 Hastings 首次报导二例利福平耐药麻风,并讨论了如何预防此种耐药性和测定麻风杆菌对利福平的敏感性。防止利福平耐药的产生,现在是推荐多种药物联合疗法以控制麻风。在1970—80年,几乎每一个国家都使用了利福平,单独使用或与其他药物联合使用。在法国的几个大城市,都是免费供给利福平,至今已有10年。从1980年开始,在 martinique 等大城市所取得的新发和复发麻风的活体组织,接种 It was Jacobson and Hastings who for the first time reported two cases of rifampin-resistant leprosy and discussed how to prevent this resistance and to determine the susceptibility of Leprosy to rifampicin. To prevent the emergence of rifampicin resistance, it is recommended that a combination of multi-drug therapy to control leprosy. In 1970-80, rifampicin was used in almost every country, alone or in combination with other drugs. In several big cities in France, rifampin is provided free of charge for 10 years. Since 1980, new and recurrent leprosy tissues obtained in major cities such as martinique have been inoculated