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目的探讨左氧氟沙星联合替硝唑治疗盆腔炎的临床疗效及安全性。方法选取吉安县横江镇卫生院2014年5月—2016年5月收治的盆腔炎患者50例,随机分为对照组和观察组,各25例。对照组患者采用左氧氟沙星联合甲硝唑治疗,观察组患者给予左氧氟沙星联合替硝唑治疗,两组患者均持续治疗7 d。比较两组患者的临床疗效及治疗前后C反应蛋白(CRP)水平、不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者CRP水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者CRP水平低于对照组(P<0.05)。观察组患者不良反应发生率低于对照组(P<0.05)。结论采用左氧佛沙星联合替硝唑治疗盆腔炎的临床疗效确切,可有效降低患者盆腔炎症,且安全性好。
Objective To investigate the clinical efficacy and safety of levofloxacin plus tinidazole in the treatment of pelvic inflammatory disease. Methods Fifty patients with pelvic inflammatory disease admitted from May 2014 to May 2016 in Hengjiang town hospital of Ji’an county were randomly divided into control group and observation group, with 25 cases in each group. Patients in the control group were treated with levofloxacin plus metronidazole, and patients in the observation group were treated with levofloxacin plus tinidazole. Both groups were treated for 7 days. The clinical efficacy and the level of C-reactive protein (CRP) before and after treatment were compared between the two groups. The incidence of adverse reactions was compared. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in CRP levels between two groups (P> 0.05). After treatment, CRP level in observation group was lower than that in control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion The clinical efficacy of levofloxacin combined with tinidazole in the treatment of pelvic inflammatory disease is accurate, which can effectively reduce pelvic inflammatory disease in patients with good safety.