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目的比较氨茶碱与舒喘灵治疗小儿咳嗽变异性哮喘的临床疗效。方法选取湖南省娄底市中心医院2015年1月—2016年6月收治的咳嗽变异性哮喘患儿132例,随机将患儿分为氨茶碱组与舒喘灵组,各66例。氨茶碱组患儿予以氨茶碱治疗,舒喘灵组患儿予以舒喘灵治疗。比较两组患儿临床疗效、症状消失时间、血常规恢复正常时间、胸部造影正常时间及治疗前后肺功能[第1秒用力呼气末容积(FEV_1)、用力肺活量(FVC)],观察两组患儿药物不良反应发生情况。结果舒喘灵组患儿临床疗效优于氨茶碱组(P<0.05)。舒喘灵组患儿症状消失时间、血常规恢复正常时间、胸部造影正常时间短于氨茶碱组(P<0.05)。治疗前两组患儿FEV_1、FVC比较,差异无统计学意义(P>0.05);治疗后舒喘灵组FEV_1、FVC低于氨茶碱组(P<0.05)。舒喘灵组患儿药物不良反应发生率低于氨茶碱组(P<0.05)。结论舒喘灵较氨茶碱治疗小儿咳嗽变异性哮喘的临床疗效好,可有效缓解患儿临床症状,改善肺功能,安全性高。
Objective To compare the clinical efficacy of aminophylline and salbutamol in the treatment of children with cough variant asthma. Methods 132 patients with cough variant asthma admitted from January 2015 to June 2016 in Loudi Central Hospital of Hunan Province were randomly divided into aminophylline group and Shuchuanling group, with 66 cases in each group. Aminophylline group to be treated with aminophylline, Shu-chuan-ling group of patients given Shu-Chuan Ling treatment. The clinical efficacy, symptom disappearance time, blood routine recovery time, normal time of chest radiography and pulmonary function (FEV_1, FVC) of two groups were compared between two groups Children with adverse drug reactions occurred. Results The clinical efficacy of Shuchuanling group was better than aminophylline group (P <0.05). The symptoms disappeared and the blood routine returned to normal in children with salbutamol group, and the duration of chest radiography was shorter than that in aminophylline group (P <0.05). There was no significant difference in FEV_1 and FVC between the two groups before treatment (P> 0.05). The FEV_1 and FVC of the Shuchuanling group were lower than those of the aminophylline group after treatment (P <0.05). The incidence of adverse drug reactions in the SF group was lower than that in the aminophylline group (P <0.05). Conclusion Shugan Ling than aminophylline treatment of children with cough variant asthma clinical efficacy is good, can effectively alleviate the clinical symptoms of children, improve lung function, high safety.