论文部分内容阅读
宫颈癌是女性常见恶性肿瘤之一,Survivin基因在宫颈癌的发生及诊断治疗中的作用是研究热点. Survivin基因促进宫颈癌发生的机制主要包括抑制肿瘤细胞凋亡、促进肿瘤细胞周期及血管形成. 肿瘤细胞抑制基因p53蛋白和人乳头瘤病毒(HPV)16 E6等可影响Survivin表达. 最近的研究发现,Survivin分子探针对宫颈癌的早期诊断特异性和敏感性很高,而且多种药物可通过下调Survivin表达水平提高宫颈癌疗效. 该文就Survivin基因在宫颈癌发生、发展、诊疗及预后评估中的研究进展予以综述,以期寻找更佳的诊断方法及治疗方案,提高宫颈癌患者的生活质量及存活率.“,”Cervical cancer is one of the most common female malignant tumors,and the role of Survivin gene is a hot research topic in the occurrence,diagnosis and treatment of cervical cancer.The mechanisms of Survivin gene promoting cervical cancer mainly include inhibiting tumor cell apoptosis ,promoting tumor cell cycle and blood vessel formation.Tumor cell suppressor p53 protein and HPV-16 E6 can influence the expression of Survivin.Recent study found that the specificity and sensitivity of Survivin molecular probes to be very high in the early diagnosis of cervical cancer,and a variety of drugs can improve the therapeutic effect by reducing Survivin expression level in cervical cancer.Here is to make a review of the research progress of Survivin gene in the genesis,development,diagnosis,treatment and prognosis assessment of cervical cancer, expecting to seek better diagnosis and treatment,and improve the life quality and survival rate of patients.