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在本文作者等所建立的小鼠缺氧预适应动物模型中 ,活性氧可能参与了缺氧预适应的形成 ,所以本研究测定了在缺氧预适应过程中活性氧的状态并将之与未经缺氧预适应的对照组小鼠进行比较。结果证明 ,缺氧 1次组小鼠脑内活性氧阳性细胞的百分数增加 ;然而 ,随着缺氧次数的增加 ,活性氧阳性细胞的百分数又降低。缺氧 4次组小鼠脑内活性氧阳性细胞百分数比缺氧 1次组显著降低 (P<0 .0 5 )。实验结果提示 :活性氧的适应性参与了小鼠缺氧耐受性的形成
In the mouse hypoxia preconditioning animal model established by the authors of this article, reactive oxygen species may be involved in the formation of hypoxic preconditioning. Therefore, this study determined the state of reactive oxygen species during hypoxia preconditioning and compared it with Hypoxic preconditioned control mice were compared. The results showed that the percentage of reactive oxygen species-positive cells increased in the first-day hypoxia mice; however, the percentage of active oxygen-positive cells decreased with the increase of the number of hypoxia. The percentages of reactive oxygen species-positive cells in brain of hypoxia group 4 were significantly lower than those of hypoxia group 1 (P <0.05). The experimental results suggest that the adaptability of reactive oxygen species is involved in the formation of hypoxia tolerance in mice