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目的探讨恶性上皮卵巢肿瘤发生的影响因素。［方法］应用１：１配对病例对照研究，收集３所医院妇科收治的恶 性上皮性卵巢肿瘤患者５２例作为病例组，收集同期住院的非妇产科、非肿瘤、与激素无关的其他女性患者５２例作为对照组，两组 间同性别、同民族、一对内年龄相差不过５岁，对所得资料进行单因素条件Ｌｏｇｉｓｔｉｃ回归分析及多元条件Ｌｏｇｉｓｔｉｃ回归分析。［结果］ 有恶性肿瘤家族史、暴露于滑石粉为上皮性卵巢癌主要的危险因素，而多产、哺乳为主要的保护因素；高促性腺激素水平及低雄 激素水平可能与上皮性卵巢癌的危险增加有关。［结论］恶性上皮性卵巢肿瘤可能为多种因素综合作用的结果，既与环境因素有 关，又与遗传因素、生殖因素和内分泌因素有关。
Objective To investigate the influencing factors of malignant epithelial ovarian tumor. [Methods] With 1: 1 matched case-control study, 52 patients with malignant epithelial ovarian tumor treated by gynecology in 3 hospitals were collected as case group, and other women with non-obstetrics and gynecology, non-tumor and hormone-related inpatients 52 cases as control group, between the two groups, the same sex, with the nationality, a pair of internal age difference of only 5 years old, the data obtained by single factor condition Logistic regression analysis and multivariate conditional Logistic regression analysis. [Results] The family history of malignant tumor exposed to talc was the main risk factor of epithelial ovarian cancer, while prolific and lactation were the main protective factors. The levels of gonadotropin and low androgen may be related to epithelial ovarian cancer Related to the increased risk. [Conclusion] Malignant epithelial ovarian tumor may be the result of the combined effect of many factors, which is not only related to environmental factors, but also related to genetic factors, reproductive factors and endocrine factors.