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目的 了解口服异维A酸治疗尖锐湿疣 (CA)的效果及其对复发的作用。方法 将门诊确诊的CA病人分为 2组 :异维A酸组 6 0例 ,给予异维A酸胶丸 10mg ,1日 3次或 1日 2次口服 ,同时用CO2 激光祛除疣体 ,每周随访 ,观察皮损变化及主要不良反应 ,并记录结果。将其中痊愈病人改为每日 1次 ,每次 10mg ,连续 1个月。停药再随访 3个月评定复发率。对照组 6 0例 ,α 干扰素 (沈阳三星生产 ) 30 0万U隔日 1次肌内注射 ,疗程及观察、记录方法同治疗组。结果 异维A酸组 :痊愈 2 4例 (4 0 0 % ) ,显效 35例 (5 8 3% ) ,无效 1例 (1 7% )。α 干扰素组 :痊愈 13例 (2 1 7% ) ,显效 4 4例 (73 3% ) ,无效 3例 (5 0 % )。两组治愈率比较差异有显著的统计学意义 (χ2 =3 76 ,P <0 0 5 )。采用口服异维A酸治疗痊愈的 2 4例病人中 ,复发 3例 ,复发率为 12 6 % ,采用肌内注射α 干扰素痊愈的 13例中 ,复发 7例 ,复发率为 5 3 8% ;异维A酸组近期复发率明显低于α 干扰素组。两组复发率的差异有显著的统计学意义 (χ2 =3 88,P <0 0 5 )。结论 口服异维A酸胶丸对CA具有较好的治疗作用 ,近期复发率较低。
Objective To investigate the effect of oral isotretinoin in the treatment of condyloma acuminatum (CA) and its effect on relapse. Methods The outpatients diagnosed with CA were divided into two groups: Isotretinoin group 60 cases, given isotretinoin capsule 10mg, on the 1st 3 times or 1 day 2 times orally, at the same time with CO2 laser to eliminate warts, each Weekly follow-up, observation of skin lesions and major adverse reactions, and record the results. Patients will be cured one day, every 10mg, for 1 month. Drug withdrawal was followed up for 3 months to assess the recurrence rate. The control group 60 cases, α interferon (Shenyang Samsung) 30 million U every other day intramuscular injection, treatment and observation, recording method with the treatment group. Results Allovarian acid group: 24 cases (40%) were cured, 35 cases (583%) were cured and 1 case (1%) were ineffective. Interferon α group: cured 13 cases (21.7%), markedly effective 4 4 cases (73 3%), invalid 3 cases (50%). There was significant difference between the two groups in the cure rate (χ2 = 3 76, P <0 05). Of the 24 patients who were treated with oral isotretinoin, 3 cases were relapsed with a recurrence rate of 12.6%. Of the 13 cases that were treated with interferon alpha intramuscular injection, 7 cases were relapsed with a recurrence rate of 53.8% The recurrence rate of isotretinoin group was significantly lower than that of interferon alpha group. The difference of recurrence rate between the two groups was statistically significant (χ2 = 3 88, P <0 05). Conclusion Oral isotretinoin capsule has a good therapeutic effect on CA, with a low recurrence rate recently.