蒽环类化疗药物包括多柔比星(阿霉素,ADM,adri amycin,or dexrazoxane)、柔红霉素(daunorubicin)、表柔比星(epirubicin)等,这些药物是肿瘤化疗中广泛应用的最有效的抗癌药物,其中ADM被认为是治疗晚期乳腺癌的标准药物,但心脏毒性的副作用成为限制其应用的重要因素,即使只用低剂量也可诱发短期及长期的心脏毒性,高剂量更甚。其引起心脏毒性机制,首先,这类药物代谢与超氧化物自由基有关,超氧化物自由基对邻近分子有很强的毒性;其次,超氧化物自由基可诱发毒性更大的羟自由基次级产物。蒽环类化疗药物与细胞内 Anthracycline chemotherapeutics include doxorubicin (ADM), adriamycin, or dexrazoxane, daunorubicin, epirubicin and the like, which are widely used in the chemotherapy of tumors Among the most effective anticancer drugs, ADM is considered as a standard drug for the treatment of advanced breast cancer. However, side effects of cardiotoxicity have become an important factor restricting its application. Short-term and long-term cardiotoxicity can be induced even at low doses. High doses Even worse. First, the metabolism of these drugs is related to superoxide radicals. Superoxide radicals are highly toxic to neighboring molecules. Second, superoxide radicals induce more toxic hydroxyl radicals Secondary product. Anthracyclines and intracellular drugs