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目的:探讨性激素失调、血脂与脂蛋白亚组分的变化与脑梗塞的关系。方法:采用放射免疫法测定急性CI患者及健康对照者的血清性激素水平,采用沉淀漂浮酶联法及乙酰丙酮显色法测定血脂与脂蛋白亚组分。结果:男性CI患者E2 显著高于正常对照组(P<0 .0 1) ,E2 / T值也明显高于对照组(P<0 .0 5 ) ,女性CI患者E2 明显低于对照组(P<0 .0 1) ,FSH、L H均明显高于对照组(均P<0 .0 5 ) ;CI组TC、L DL- C明显高于对照组;男性E2 与TC、L DL- C呈正相关(均P<0 .0 5 ) ,与HDL- C、HDL2 - C、HDL3- C呈负相关(均P<0 .0 5 ) ;E2 / T与TC、L DL- C呈正相关(均P<0 .0 5 ) ,与HDL- C、HDL2 - C、HDL3- C负相关(均P<0 .0 5 ) ,女性E2 与TC、L DL- C呈负相关(均P<0 .0 5 ) ;与HDL- C、HDL2 - C呈正相关(均P<0 .0 1)。结论:脑梗塞性患者存在严重的性激素失调及脂质代谢异常,性激素及血脂代谢紊乱参与了脑梗塞的发病机制。
Objective: To investigate the relationship between sex hormone imbalance, blood lipids and lipoprotein subfractions and cerebral infarction. Methods: Serum sex hormone levels were measured by radioimmunoassay in patients with acute CI and healthy controls. Lipid and lipoprotein subfractions were determined by sedimentation and enzyme-linked immunosorbent assay. Results: E2 in male CI patients was significantly higher than that in normal controls (P <0.01), E2 / T values were also significantly higher in control group (P <0.05), E2 in female CI patients was significantly lower than that in control group P <0.01), FSH, LH were significantly higher than the control group (all P <0. 05); CI group TC, L DL-C was significantly higher than the control group; male E2 and TC, (P <0.05), but negatively correlated with HDL-C, HDL2-C and HDL3-C (all P <0.05); E2 / T was positively correlated with TC and L DL-C (All P <0.05), but negatively correlated with HDL-C, HDL2-C and HDL3-C .0 5), but positively correlated with HDL-C and HDL2-C (all P <0.01). Conclusion: There are severe sex hormone disorders and abnormal lipid metabolism in patients with cerebral infarction. Sex hormones and dyslipidemia are involved in the pathogenesis of cerebral infarction.