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疟疾是由疟原虫引起的虫媒传染病。近些年,由于疟原虫抗药性的产生和迅速扩散,给疟疾治疗带来严重困难,因此,研制安全有效的疫苗是预防疟疾感染,控制疟疾流行的主要手段之一。疟原虫致病机制研究已经成为研制抗疟疫苗及疾病防控的一项重点,由于多种疟原虫输出型蛋白能够运输到宿主细胞表面进行信息传递并可使虫体逃避宿主的免疫反应,因此研究虫体输出型蛋白转运机制对疟原虫致病机制研究有着至关重要的意义。本文概述了疟原虫蛋白输出的机制,以及NPPs、TVN、MCs、Knobs和PTEX等5种疟原虫重要的蛋白输出结构的研究进展。
Malaria is an insect-borne infectious disease caused by Plasmodium. In recent years, due to the emergence and rapid spread of drug resistance of Plasmodium, which brings serious difficulties in the treatment of malaria. Therefore, developing a safe and effective vaccine is one of the main measures to prevent malaria infection and control malaria epidemic. Studies on the pathogenesis of Plasmodium have become an important topic in the development of antimalarial vaccine and disease prevention and control. Because a variety of Plasmodium export protein can transport to the host cell surface to transmit information and make the parasites evade host immune response, Studying the export-type protein transport mechanism of parasites is of great significance to the pathogenesis of Plasmodium. This article summarizes the mechanism of the protein export of Plasmodium and the research progress on the important protein export structures of five species of Plasmodium, such as NPPs, TVN, MCs, Knobs and PTEX.