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为探讨子宫全切除对患者免疫功能的影响及影响因素,采用双抗夹心法和放免法对61名子宫全切患者术前及术后3、6个月血清可溶性白细胞介素-2受体(sIL-2R)水平及雌、孕激素进行测定。结果,子宫全切除患者术后3个月血清sIL-2R为(271.71±75.86)mu/L,术后6个月为(330.14±69.81)mu/L,均高于术前的(200.43±112.18)mu/L和对照组的(211.1±134.29)mu/L。术后6个月卵泡期和围排卵期雌二醇分别为(107.98±57.45)pmol/L和(153.38±95.21)pmol/L,均显著低于术前的(20816±11218)pmol/L和(517.24±236.93)pmol/L;黄体期孕酮为(23.13±11.16)nmol/L,也较术前的(86.36±28.19)nmol/L明显下降。提示子宫切除术后体内免疫功能紊乱及卵巢功能衰退,免疫功能紊乱可能与卵巢功能衰退有关。
To investigate the effect of total hysterectomy on immune function and its influencing factors, the serum levels of soluble interleukin-2 receptor (IL-6R) in 61 hysterectomy patients before surgery and 3 and 6 months after operation were measured by double-antibody sandwich method and radioimmunoassay sIL-2R) levels and estrogen and progesterone were measured. Results: The sIL-2R of the total hysterectomy patients was (271.71 ± 75.86) mu / L at 3 months and (330.14 ± 69.81) mu / L at 6 months after operation, both of which were significantly higher than those of preoperative (200.43 ± 112.18 ) mu / L and (211.1 ± 134.29) mu / L in the control group. The estradiol levels in the follicular and peri-ovariectomized groups at 6 months after operation were (107.98 ± 57.45) pmol / L and (153.38 ± 95.21) pmol / L, respectively, which were significantly lower than those of preoperative (20816 ± 11218 pmol / L and (517.24 ± 236.93) pmol / L, and the progesterone in the luteal phase was (23.13 ± 11.16) nmol / L, which was also significantly lower than that before the operation (86.36 ± 28.19 nmol / L) Prompt hysterectomy in vivo immune dysfunction and ovarian function decline, immune dysfunction may be related to ovarian dysfunction.