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目的分析山东省居民代谢综合征(MS)与微量白蛋白尿(MAU)的关系,为MAU的防控提供依据。方法于2011年在山东省采用4阶段分层随机抽样方法抽取2 184名18~69岁居民作为研究对象,测量其血糖、血脂、24 h尿微量白蛋白和尿肌酐等指标。采用SAS 9.3软件对数据进行统计分析,计量资料的比较用t检验,计数资料的比较用χ2检验,采用二分类logistic模型分析MS的影响因素。结果最终资料完整并符合要求的1 904名研究对象纳入本研究。MS患病率为24.7%。经多因素logistic模型分析,与非MS者相比,MS患者MAU患病风险OR值(95%CI)为2.71(1.69~4.36)。在MS各组分中,中心性肥胖、血压升高和血糖升高均与MAU患病风险存在正相关。此外,与不具有MS组分者相比,具有1、2、3、4和5个MS组分者MAU患病风险OR值(95%CI)分别为1.19(0.55~2.58)、1.32(0.59~2.93)、2.57(1.20~5.51)、3.92(1.67~9.20)和5.66(1.82~17.63),趋势检验有统计学意义(P<0.01)。结论 MS是MAU的一个重要危险因素。
Objective To analyze the relationship between metabolic syndrome (MS) and microalbuminuria (MAU) in Shandong Province and provide the basis for the prevention and control of MAU. Methods A total of 2 184 inhabitants aged 18-69 years were enrolled in Shandong Province in 2011 by stratified random sampling method. The blood glucose, blood lipid, 24h urinary albumin and urinary creatinine were measured. SAS 9.3 software was used to analyze the data statistically. The comparison of measurement data was performed by t-test. The comparison of count data was analyzed by χ2 test. The dichotomous logistic model was used to analyze the influential factors of MS. Results A total of 1 904 subjects with completed data and satisfactory results were included in the study. The prevalence of MS was 24.7%. Multivariate logistic regression analysis showed that the odds ratio (95% CI) of MAU prevalence in MS patients was 2.71 (1.69-4.46) compared with non-MS patients. Among MS components, central obesity, elevated blood pressure and elevated blood glucose are positively correlated with the prevalence of MAU. In addition, odds ratios (95% CI) for MAU with 1, 2, 3, 4, and 5 MS fractions were 1.19 (0.55-2.58), 1.32 ~ 2.93), 2.57 (1.20 ~ 5.51), 3.92 (1.67 ~ 9.20) and 5.66 (1.82 ~ 17.63) respectively. The trend test was statistically significant (P <0.01). Conclusion MS is an important risk factor for MAU.