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目的 探讨尼莫地平对蛛网膜下腔出血 (SAH)后脑血管痉挛所致神经功能损伤的保护作用。方法 对单纯SAH组和尼莫地平处理组大鼠观察手术前后基底动脉管径 ,并检测局部脑血流量 (rCBF)、体感诱发电位(SEP)及脑组织内皮素 1(ET 1)含量的动态变化。结果 SAH组大鼠在诱导SAH后rCBF立即降低 ,并持续 2 4h ,同时有基底动脉痉挛 ;SAH后 1h开始至 2 4hSEP潜伏期逐渐延长 ,脑组织ET 1含量显著增加。尼莫地平使上述变化均明显减轻。结论 尼莫地平对SAH后脑血管痉挛所致神经功能损伤具有保护作用 ,其机理之一为拮抗脑组织ET 1的异常变化
Objective To investigate the protective effect of nimodipine on neurological injury induced by cerebral vasospasm after subarachnoid hemorrhage (SAH). Methods The diameters of basilar artery before and after surgery were observed in SAH group and nimodipine group. The dynamic changes of regional cerebral blood flow (rCBF), somatosensory evoked potential (SEP) and endothelin 1 (ET 1) Variety. Results In SAH group, rCBF decreased immediately after induction of SAH and continued for 24 hours with basilar artery spasm. The latency of SEP gradually increased from 1 hour to 24 hours after SAH, and the content of ET 1 in brain tissue increased significantly. Nimodipine significantly reduced these changes. Conclusion Nimodipine has a protective effect on neurological injury induced by cerebral vasospasm after SAH. One of the mechanisms is to antagonize the abnormal changes of ET 1 in brain tissue