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严重创伤、误吸或其他吸入性损伤、重症感染是诱发急性呼吸窘迫综合症(Acute Respiratory DistressSyndrome,ARDS)的倾向性因素.各种因素导致肺损伤的进一步加重,其临床表现就是ARDS.目前一般采用非特异性方法来纠正ARDS病人的异常的渗出性或创伤性炎症反应,目的在于急性肺损伤消散过程中维持细胞和生理的功能(如气体交换、器官灌流和需氧代谢).但是还缺乏特异的治疗方法.在最近几年的研究中,吸入一氧化氮(Nitric Oxide,NO)治疗ARDS己受到一定程度的重视,在国内外均已进行了大量的基础与临床研究,并获得很大的进展.1 NO的生物学特性1986年Furchgott和Ignarro首先提出内皮细胞血管
Severe trauma, aspiration or other inhalation injury, severe infection is a predisposing factor for the induction of acute respiratory distress syndrome (ARDS) .A variety of factors lead to further aggravating lung injury, the clinical manifestations of which is ARDS. A nonspecific approach is used to correct abnormal exudative or traumatic inflammatory responses in ARDS patients with the goal of maintaining cellular and physiological functions (eg, gas exchange, organ perfusion, and aerobic metabolism) during the resolution of acute lung injury but is also lacking Specific treatment in recent years, the study, the inhalation of nitric oxide (NO) treatment of ARDS has received some attention, both at home and abroad have carried out a large number of basic and clinical studies, and get very large .1 The Biological Characteristics of NO Furchgott and Ignarro first proposed endothelial cell vessels