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目的 探讨内皮素 (ET1 )、血栓烷 (TXA2 )和前列环素(PGI2 )在小儿中枢神经系统感染 (FCNS)中的意义。方法 采用放射免疫方法检测 FCNS儿脑脊液 (CSF)中 ET1 及 TXA2 和 PGI2 的稳定代谢产物 TXB2 和 6 - k-PGF1α,非感染手术儿 CSF为对照。结果 FCNS儿 CSF、ET1 、TXB2 及 TXB2 /6 - k- PGF1α(T/K)比值升高 ,昏迷儿 CSF、ET1 、TXB2 高于非昏迷儿 ,恢复期 CSF、ET1 、TXB2 /6 - k- PGF1α比值较急性期下降。结论 FCNS时神经系统 ET1 和 TXA2 生成增加 ,CSF中 ET1 、TXB2 和 6 - k- PGF1α改变可反映脑实质损伤程度 ,有助于临床病情判断。
Objective To investigate the significance of endothelin (ET1), thromboxane (TXA2) and prostacyclin (PGI2) in children with central nervous system infection (FCNS). Methods The stable metabolites TXB2 and 6 - k - PGF1α of ET1, TXA2 and PGI2 in CSF of CSF were detected by radioimmunoassay. CSF of non - infected children was used as control. Results The ratios of CSF, ET1, TXB2 and TXB2 / 6 - k - PGF1α (T / K) in FCNS children were higher than those in non - coma children. The levels of CSF, ET1, TXB2 / PGF1α ratio than the acute phase decreased. Conclusion The production of ET1 and TXA2 in the nervous system is increased during FCNS. The changes of ET1, TXB2 and 6 - k - PGF1α in CSF may reflect the extent of parenchymal damage and contribute to the judgment of clinical conditions.