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目的：探讨小针刀联合氟比洛芬巴比膏贴敷治疗骨性膝关节炎的临床效果。方法：选择于我院就诊并符合骨性膝关节炎诊断标准的患者60例，按就诊顺序随机分为两组，每组30例。Ⅰ组为针刀联合氟比洛芬巴比膏贴敷治疗组，Ⅱ组为针刀治疗组。观察两组患者治疗前后视觉模拟评分（VAS 评分）、膝关节功能评分（Lysholm）及临床疗效。结果：两组患者治疗后 VAS 评分均低于治疗前（P ﹤0.05），治疗后Ⅰ组又显著低于Ⅱ组，差异均有统计学意义（ P ﹤0.05）；两组患者治疗后 Lysholm 膝关节功能评分均高于治疗前，治疗后Ⅰ组又显著高于Ⅱ组，差异均有统计学意义（P ﹤0.05）；治疗后临床效果（优良率）Ⅰ组显著高于Ⅱ组（P ﹤0.05）。结论：小针刀联合氟比洛芬巴比膏贴敷治疗骨性膝关节炎临床疗效显著，止痛效果确切、作用持久、无副作用及胃肠道不良反应，其疗效优于单独采用小针刀的治疗。“,”OBJECTIVE: To explore the clinical efficacy of a small needle -knife therapy combined with of flurbiprofen Bob paste in the treatment of knee osteoarthritis.METHOD: 60 patients with knee osteoarthritis in our hospital were chosen and divided random-ly into groupⅠ (n =30) and group Ⅱ (n =30).GroupⅠreceived a small needle -knife therapy combined with flurbiprofen Bob paste.Group Ⅱ only received a small needle -knife therapy.The effect of analgesia by VAS pain score, Lysholm and clinical effica-cy before and after treatment were evaluated.RESULTS: The VAS pain scores of two groups after treatment were lower than those be-fore treatment (P <0.05); and VAS pain score of group Ⅰ was significantly lower than that in group Ⅱ after treatment.There was a significant difference (P <0.05).The value of Lysholm in two groups after treatment was higher than that before treatment (P <0.05); and the value of Lysholm of group Ⅰ was significantly higher than that in group Ⅱ after treatment.There were significant difference (P <0.05).The excellent rates representing clinical efficacy in group Ⅰ were significantly higher than those in group Ⅱafter treatment (P <0.05).CONCLUSION: A small needle -knife therapy combined with flurbiprofen Bob paste may treat knee os -teoarthritis effectively and can achieve exactly analgesic effect.There are no side effects and gastrointestinal adverse reactions.Conse-quently the curative effect for using joint treatment is rather better than that for simply using a small needle -knife therapy in the treat-ment of knee osteoarthritis.