目的:分析黄芩射干汤血中移行成分随时间的变化规律。方法:采用血清药物化学研究方法,测定黄芩射干汤进入大鼠体内的化合物数目及其随时间的变化。结果:确定了大鼠血清中13个血中移行成分中的5个化合物(2#鸢尾黄素、5#野鸢尾黄素、8#黄芩素、11#次野鸢尾黄素和12#汉黄芩素)。在确定的射干黄酮类成分中,化合物均以射干苷元形式存在,未检测到射干苷类;色谱峰1,5,6,7,9,10和11号吸收入血后较快完成代谢,240 min内血中基本检测不到药物原型。结论:黄芩射干汤的药效物质基础很可能与5个血中移行成分相关。 OBJECTIVE: To analyze the variation of migration components of Shuiqin Shegan Decoction over time. Methods: Serum drug chemistry method was used to determine the number of compounds entering the body of Scutellaria Shegangan Decoction and its change with time. RESULTS: Five compounds (2 # tectorigenin, 5 # tectorigenin, 8 # baicalein, 11 # myury tectorite and 12 # Wogonin) were identified in the 13 blood components of the rat serum . In the determined flavonoid components, the compounds were all present in the form of cantharidin, and none of the compounds were detected. Peaks 1, 5, 6, 7, 9, 10 and 11 were absorbed into the blood and metabolized rapidly, Within 240 min, almost no drug prototype was detected in the blood. Conclusion: The medicinal substance of Scutellaria Shegangan Decoction is likely to be related to five components of blood migration.