Purpose:To evaluate the long-term outcomes of a non-valved,.Chinese-made Hunan aqueous drainage device(HAD) in patients with refractory glaucoma,.compared to trabeculectomy.Methods:This was a retrospective observational case series,including 27 patients with refractory glaucoma who either underwent HAD implantation (n=11) or trabeculectomy (n=16).The mean follow-up was 27.9±13.5 (mean±SD) months.Intraocular pressure(IOP),visual acuity and postoperative complications were measured.Results:IOP was significantly lower at the last follow-up in both two groups compared with the baseline IOP (HAD:58.4 to 19.0 mmHg,P<0.001;trabeculectomy:58.4 to 23.7 mmHg,P<0.001).One week,1 month and 1 year after the operation,the average IOP of the HAD group was significantly lower than that of trabeculectomy group(P<0.05 at all time points).However,the IOP did not differ significantly between the two groups at the time of last follow-up.Conclusion:HAD implantation serves as a good option to control IOP in refractory glaucoma. Purpose: To evaluate the long-term outcomes of a non-valved, .Chinese-made Hunan aqueous drainage device (HAD) in patients with refractory glaucoma, .compared to trabeculectomy. Methods: This was a retrospective observational case series, including 27 patients with mean duration of 27.9 ± 13.5 (mean ± SD) months. Intraocular pressure (IOP), visual acuity and postoperative complications were measured Results: IOP was significantly lower at the last follow-up in both two groups compared with the baseline IOP (HAD: 58.4 to 19.0 mmHg, P <0.001; trabeculectomy: 58.4 to 23.7 mmHg, P <0.001) month and 1 year after the operation, the average IOP of the HAD group was significantly lower than that of trabeculectomy group (P <0.05 at all time points). However, the IOP did not differ significantly between the two groups at the time of last follow-up.Conclusion: HAD implantation serves as a good option to control IOP i n refractory glaucoma.