血管生成在实体肿瘤的生长和转移等生物行为中具有重要的调节作用。对于肿瘤新生血管生成过程进行成像,可以为临床提供病变探测、药物应用筛选、治疗有效性评价和监测、疾病预后等多方面的大量重要信息。分子成像的发展为该领域的研究提供了新的空间和应用平台。主要对整合素αⅤβ3在肿瘤新生血管分子成像中的应用及其最新进展进行综述。 Angiogenesis plays an important regulatory role in biological behavior such as growth and metastasis of solid tumors. Imaging tumor neoangiogenesis process can provide a large number of important information for clinic in many aspects such as lesion detection, drug application screening, evaluation and monitoring of therapeutic effectiveness, disease prognosis and so on. The development of molecular imaging provides a new space and application platform for the research in this field. The main application of integrin αVβ3 in tumor angiogenesis molecular imaging and its recent progress are reviewed.