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Objective To investigate the improvement of Xanthoceraside on learning and memory impairment in mice induced by intracerebroventricular injection of Aβ1-42(i.c.v.Aβ1-42)and the possible mechanisms of its protection against AD.Methods Y-maze test,water-maze test and step-down test were used to investigate the learning and memory ability of mice;Biochemical analysis was used to detect the activity of CAT,T-AOC,ATPase and the content of MDA.Results The results showed that Xanthoceraside could significantly increase the alternation behavior in Y-maze test,shorten swimming time in water maze test and increase the latency and decrease the number of errors and the total time of shock in step-down test.Xanthoceraside markedly increased the activity of CAT,T-AOC,ATPase,at the same time,decreased the content of MDA.Conclusions Xanthoceraside can improve learning and memory impairment in mice induced by i.c.v.Aβ1-42 significantly.The mechanism may be associated with the protection against damage induced by free radicals;the inhibition of membrane lipid peroxidation and the improvement of metabolism of brain.
Objective To investigate the improvement of Xanthocera on on memory and memory impairment in mice induced by intracerebroventricular injection of Aβ 1-42 (icvAβ 1-42) and the possible mechanisms of its protection against AD. Methods Y-maze test, water-maze test and step -down test were used to investigate the learning and memory ability of mice; Biochemical analysis was used to detect the activity of CAT, T-AOC, ATPase and the content of MDA. Results of the results showed that Xanthocera could not increase the alternation behavior in Y-maze test, shorten swimming time in water maze test and increase the latency and decrease the number of errors and the total time of shock in step-down test. Xanthoceracted markedly increased activity of CAT, T-AOC, ATPase, at the same time, decreased the content of MDA.Conclusions Xanthoceraside can improve learning and memory impairment in mice induced by icvAβ1-42 significantly.The mechanism may be associated with the protection against dama the induced of free lipid; the inhibition of membrane lipid peroxidation and the improvement of metabolism of brain.