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肺癌是当今致死率最高的恶性肿瘤，脑转移是导致高死亡率的一个重要原因。精准诊断脑转移对于患者的治疗和预后意义重大。分子检测敏感度高，在肺癌脑转移诊断中具有很大的应用前景，而生物标志物的探索也因此受到人们越来越多的关注。本文主要从原发灶、转移灶、外周血和脑脊液分别阐述与肺癌脑转移发生相关的生物标志物研究进展，其中脑脊液中生物标志物检测可能是未来诊断和治疗的重要检测方式，为今后开展有关肺癌脑转移多组学诊断的研究提供理论依据。“,”Lung cancer is the most deadly malignancy in the world. Brain metastasis is an important cause of the high mortality. The accurate diagnosis of brain metastases is of great significance for the treatment and prognosis of patients. Molecular detection has great application prospect on the diagnosis of lung cancer with brain metastases depended on the high sensitivity, and therefore the exploration of biomarkers has attracted more and more attention. This article will review advances in biological markers research of lung cancer with brain metastases in terms of the primary lesions, metastatic lesions, peripheral blood and cerebrospinal fluid. With the development of the relevant research, the detection of biomarkers in cerebrospinal fluid may be an important method on the diagnosis and treatment of lung cancer with brain metastases in the future, which provide a theoretical basis for the multi-omics study on diagnosis of lung cancer with brain metastases.