To search for potent insecticides targeting at ryanodine receptors(RyRs),a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized.Their insecticidal activities were evaluated and the preliminary struc-ture-activity relationships(SARs)were discussed.The insecticidal results showed that some of the compounds(8a-8h,8m,8n)ex-hibited good larvicidal activities against oriental armyworm at 2.5 mg·L-1,and compound 8m possessed 60％insecticidal activity at 0.5 mg·L-1.For diamondback moth,8m exhibited better activity than Chlorantraniliprole at a hundred fold preference.The calcium imag-ing technique experiment results suggested that compound 8m could increase the intracellular[Ca2+]1· With the neurons preincubat-ed experiment,the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of ori-ental armyworm.The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.