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腭、肺及鼻咽上皮克隆(palate,lung,and nasal epithelium clone,PLUNC)家族为一新近发现的具有宿主防御功能的蛋白质家族,它们大多存在于呼吸道上皮与消化道上皮的表面,在上皮组织与外界各种信号之间起着信号传递中介与信号执行分子的作用.在迄今为止发现的人类10个PLUNC家族成员中,我们所克隆的NASG基因即为这一免疫保护分子家族的成员,对其结构与功能分析表明,它属于SPLUNC1(short palate,lung,and nasal epithelium clone 1)的全新转录本,具有杀菌/渗透增强蛋白质结构域,能对外来物理及化学刺激做出反应,并具有抗微生物、清除有害化学物质、抗肿瘤等多重功效.SPLUNC1作为上呼吸道的一种新的天然免疫保护分子,在维持上呼吸道的正常生理活动以及抗炎杀菌抑瘤中起着重要作用.
The palate, lung and nasopharyngeal epithelial clone (PLUNC) family is a newly discovered protein family with host defense function. Most of them are found on the surface of respiratory epithelium and gastrointestinal epithelium, And all kinds of signals with the outside world plays a role of signaling intermediary and signal execution molecule in the so far found 10 human members of the PLUNC family, we cloned NASG gene is a member of this family of immune protection, Its structural and functional analysis shows that it belongs to the new transcript of SPLUNC1 (short palate, lung, and nasal epithelium clone 1), has a bactericidal / osmotic enhanced protein domain that reacts to external physical and chemical stimuli and has anti Microbes, the removal of harmful chemicals, anti-tumor, etc. SPLUNC1, as a new natural immune protective molecule in the upper respiratory tract, plays an important role in maintaining the normal physiological activity of the upper respiratory tract and anti-inflammatory and antitumor effects.