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为了观察头孢地嗪在不同肾功能损害伴感染病人的免疫增强作用 ,在不同肾功能损害伴感染的两组24例病人中 ,采用随机方法观察了静脉注射头孢地嗪1.0gbid及头孢噻肟钠1.0gtid各10d后 ,两组病人的感染均得到控制 ,其中头孢地嗪组总T淋巴细胞 (CD3)T辅助淋巴细胞 (CD4)升高、T抑制淋巴细胞 (CD8)略有下降、CD4/CD8 升高 (接近正常),可溶性白细胞介素2受体 (sIL -2R)下降;而头孢噻肟钠组则无明显变化。结论 :头孢地嗪对免疫功能低下伴感染的病人有免疫增强作用。
In order to observe the effect of cefodizime on immune enhancement in patients with different renal dysfunction and infection, 24 patients in two groups with different renal dysfunction and infection were randomized to receive cefodizime 1.0gbid and cefotaxime sodium After 10 days of 1.0gtid infection, the infection of both groups was controlled. The levels of T lymphocyte (CD4) CD8 increased (close to normal), soluble interleukin 2 receptor (sIL -2R) decreased; cefotaxime sodium group had no significant change. Conclusion: Cefodizime has immune enhancement effect on patients with immunocompromised infection.