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自从1937年发现癞皮病的发生是由于缺乏尼克酸之后,人们就想找出尼克酸的需要量,如Dann1944根据分析一些膳食与癞皮病的关系之后,认为人体尼克酸的最低需要不超过10毫克。Frazier和Friedmann在作同样的分析时,发现在不同的膳食条件下,尼克酸的需要量不同。但直到以后色氨酸与尼克酸的关系被阐明以后,人们才对尼克酸需要量有了比较明确的认识。首先是在1946年Rosen等人报告给白鼠服用色氨酸之后,能使其尿中排出尼克酸代谢产物增高。1947年Sarett和Goldsmith及Perlzweig等人也在人体证明服用色氨酸之后能增加尿中甲基尼克酰胺的排出量。
Since it was discovered in 1937 that nilosis is caused by the lack of niacin, people wanted to find the amount of nicotinic acid required. For example, Dann1944, after analyzing the relationship between some diets and nilosis, concluded that the minimum requirement of niacin does not exceed 10 mg. In the same analysis, Frazier and Friedmann found that nicotinic acid required different amounts under different dietary conditions. However, until after the relationship between tryptophan and niacin is elucidated, people have a more clear understanding of niacin requirements. The first is Rosen et al reported in 1946 to rats taking tryptophan, can make its urinary nicotinic acid metabolites excreted. In 1947 Sarett and Goldsmith and Perlzweig, who also in human body after taking tryptophan can increase urinary methyl nicotinamide emissions.