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Isothiazolone具有广谱的抗菌作用,尤其在防霉方面效果显著。用0.1％的水溶液对标本作防腐观察3年,见溶液清晰,标本色泽无变化,大体结构层次清楚,无霉菌生长。光镜下观察动物防腐标本的组织切片,结构清楚,细胞完整。抑菌试验表明,0.05％-0.1％的水溶液对常见污染细菌及霉菌均有良好抑制作用。对长霉标本上分离出来的黄曲霉菌等,抑制效果可靠。Isothiazolone水溶液稳定,半分解期为93.28月,按0.1％水溶液投料防腐,抑霉作用可保存7年有效。其水溶液无色,无味,无刺激。毒性试验结果,LD_(so)为175mg/kg,Ames法突变试验阴性,致畸实验表明不引起胎鼠骨骼畸形。
Isothiazolone has a broad spectrum of antibacterial effects and is particularly effective in preventing mildew. With 0.1% aqueous solution for the preservation of specimens for 3 years, see the solution clear, no change in specimen color, the general structure of the level clear, no mold growth. Light microscope observation of animal antiseptic specimens of tissue sections, clear structure, cell integrity. Bacteriostasis tests showed that 0.05% -0.1% aqueous solution of common bacteria and fungi have a good inhibitory effect. Aspergillus flavus mold isolated on the mold, the inhibition effect is reliable. Isothiazolone solution stability, semi-decomposition period of 93.28 months, 0.1% aqueous solution feed antiseptic effect can be stored for 7 years effective. Its aqueous solution is colorless, odorless, non-irritating. Toxicity test results, LD_ (so) was 175mg / kg, Ames mutation test was negative, teratogenic experiments showed that fetal rat skeletal malformations did not cause.