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近年有不少作者报导了肌萎缩侧索硬化(ALS) 病人的免疫异常情况,并提出了该病的免疫病因,但证据尚不充分。为了收集ALS 病人的免疫系统可能受累的更多资料,作者选择ALS 病人、多发性硬化(MS)病人进行研究,将其血清和脑脊液的免疫学参数进行比较分析。共分三组。第一组为早期ALS(平均年龄59岁),第二组为临床确诊的进展性MS(平均年龄33岁),第三组为对照组(平均年龄56岁),各组均为30例。上述研究对象均无自身免疫性疾病、感染性疾病或肿瘤,并在研究前6个月内未进行过免疫调节治疗。结果提示;ALS 病人脑脊液IgG 和IgG 指数正
In recent years, many authors have reported the immune abnormalities in patients with amyotrophic lateral sclerosis (ALS), and put forward the immune etiology of the disease, but the evidence is not sufficient. In order to collect more information on the possible involvement of the immune system in patients with ALS, the authors selected patients with ALS and patients with multiple sclerosis (MS) to conduct a comparative analysis of their immunological parameters in serum and cerebrospinal fluid. Divided into three groups. The first group was early ALS (average age 59 years), the second group was clinically diagnosed as progressive MS (mean age 33 years), the third group was control group (mean age 56 years), and each group was 30 cases. None of the above subjects had an autoimmune disease, an infectious disease, or a tumor and did not receive immunomodulatory treatment within the first 6 months of the study. The results suggest that ALS patients with cerebrospinal fluid IgG and IgG index positive