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目的 探讨支气管哮喘患者血清中白介素－ ４（ＩＬ－ ４）、可溶性细胞粘附因子－１（ｓＩＣＡＭ－ １）、γ干扰素在支气管哮喘发病中的作用及与ＩｇＥ水平的相关关系。方法 分别在支气管哮喘发作期、缓解期及口服强的松治疗后用ＥＬＩＳＡ双抗体夹心法分别测定血清中ＩＬ－４、ｓＩＣＡＭ－ １、ＩＦＮγ和ＩｇＥ水平。结果 在支气管哮喘发作期血清ＩＬ－４、ｓＩＣＡＭ－１、ＩｇＥ水平明显升高，ＩＦＮγ水平明显降低；在缓解期和经强的松治疗后，血清ＩＬ－４、ｓＩＣＡＭ－ １、ＩｇＥ水平明显降低。结论 ＩＬ－４ 可促进ｓＩＣＡＭ－１ 表达及ＩｇＥ分泌，并可抑制ＩＦＮγ的分泌，因此在支气管哮喘发病中起重要作用。
Objective To investigate the role of serum interleukin-4 (IL-4), soluble cell adhesion molecule-1 (sICAM-1) and interferon-γ in bronchial asthma and their relationship with IgE levels in patients with bronchial asthma. Methods Serum levels of IL-4, sICAM-1, IFNγ and IgE were measured respectively by ELISA double antibody sandwich method after bronchial asthma attack, remission and oral prednisone treatment. Results Serum levels of IL-4, sICAM-1 and IgE were significantly increased and the level of IFNγ was significantly decreased in the episodes of bronchial asthma. Serum levels of IL-4, sICAM-1 and IgE were significantly decreased in remission and prednisone treatment . Conclusion IL-4 can promote sICAM-1 expression and IgE secretion, and inhibit the secretion of IFNγ, and therefore play an important role in the pathogenesis of bronchial asthma.