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据报道溃结和克隆病患者接受静脉内免疫球蛋白(IVIG)治疗后可改善临床表现,为进一步评价此方法的疗效,作者对需用类固醇激素才能保持缓解,或对标准内科治疗无效的活动广泛的特发性结肠炎病人采用IVIG治疗。材料与方法:病人共12例,8男,4女,9例为溃结,3例为克隆结肠炎,均根据病史、临床表现、内镜和活检结果确诊。所有病人均接受类固醇激素治疗,无免疫抑制剂治疗和外科手术史。治疗前1周和治疗后第12周、24周行结肠镜检查,并取活检。在诱导期将2g/kg的IVIG分二天或五天输入
It has been reported that patients with UC and Crohn’s disease can improve their clinical performance after intravenous immunoglobulin (IVIG) treatment. To further evaluate the efficacy of this method, the authors evaluate whether steroid-lowering hormones are needed to maintain remission or to be ineffective with standard medical therapy A wide range of idiopathic colitis patients treated with IVIG. Materials and Methods: A total of 12 patients, 8 males and 4 females, 9 patients with ulceration and 3 colonies with colitis were diagnosed according to their medical history, clinical manifestations, endoscopy and biopsy results. All patients received steroid therapy, no immunosuppressive therapy and a history of surgery. One week before treatment and 12 weeks after treatment, colonoscopy was performed at 24 weeks and biopsy was performed. IVIG at 2 g / kg was administered on two or five days during the induction period