【摘 要】
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Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia (ET) in a patient is extremely rare,with only 10 cases reported thus far in lite
【机 构】
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Department of Hernatology,Laboratory of Hematology
论文部分内容阅读
Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia (ET) in a patient is extremely rare,with only 10 cases reported thus far in literature.This paper describes a 94-year-old male having atypical B-CLL with CD5- (CD5-) phenotype and ET.In this patient,we performed interphase fluorescence in situ hybridization (FISH) analysis which revealed 13q14.3 deletion in 31％ of B-lymphocyte nuclei and RB1 deletion in 27％ of B-lymphocyte nuclei,but not in neutrophils and T-lymphocytes.Furthermore,we identified JAK2 V617F mutation in the peripheral blood nucleated cells and neutrophils,but not in the B- and T-lymphocyte populations.Therefore,it was concluded that the occurrence of CD5- B-CLL and ET in this patient was pathogenically independent.
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