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目的通过对乙型病毒性肝炎(乙肝)重叠戊型病毒性肝炎(戊肝)(CHB-E)患者与单纯戊肝(HE)患者淋巴细胞及亚群和体液免疫功能、肝功能等指标的测定分析各组之间的差异。方法收集CHB-E患者78例[其中乙肝病毒e抗原阳性(HBeAg+)者33例,HBeAg-者45例]及HE感染患者51例,分别用血球仪进行淋巴细胞(LC)计数,流式细胞仪测定CD3、CD4、CD8、自然杀伤细胞(NK)、B淋巴细胞(BC),免疫比浊法测定IgG/IgA/IgM,生化法测定丙氨酸转移酶(ALT)、胆红素(TBIL)及血凝仪测定凝血酶原时间(PT)。并分析各组间差异。结果 HBeAg+组与HE组在CD8与NK,HBeAg-组与HE组在LC、CD3、CD4和NK,HBeAg+组与HBeAg-组在LC、CD3和CD4之间有差异。免疫球蛋白只有IgM在HBeAg+组与HE组、HBeAg+组与HBeAg-组之间有差异。HBeAg+组、HBeAg-组与HE组在ALT、TBIL之间有统计学差异。HBeAg+组与HBeAg-组ALT之间有差异。结论 CHB-E感染患者中两种病毒可能产生了一定的干扰,并较HE引起的肝损害有所减轻。
Objective To investigate the effects of hepatitis B virus (HEV) on hepatitis B virus (HEV), hepatitis B virus (Hepatitis E) Determination of differences between groups. Methods Totally 78 patients with CHB-E (including 33 HBeAg positive and 45 HBeAg-positive) and 51 HE-infected patients were enrolled. Blood samples were collected for lymphocyte (LC) counting, flow cytometry The levels of CD3, CD4, CD8, NK and B lymphocytes (BC) were determined by ELISA. IgG / IgA / IgM were measured by turbidimetric assay and the alanine aminotransferase (ALT) and bilirubin ) And coagulometer prothrombin time (PT). And analyze the differences among groups. Results There were differences in LC, CD3, CD4 and NK between HBeAg + group and HE group on CD8 + NK group, HBeAg- group and HE group on LC, CD3 and CD4. Only IgM of immunoglobulins differed between HBeAg + group and HE group, HBeAg + group and HBeAg- group. There was a significant difference between ALT and TBIL in HBeAg + group, HBeAg- group and HE group. There is a difference between HBeAg + group and HBeAg- group ALT. Conclusions The two viruses in CHB-E infected patients may have certain interference, which is less than the liver damage caused by HE.