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自身免疫性疾病(ADs)是以特定的靶器官或多个器官系统的慢性损害和功能障碍为特征,临床上缺乏有效的治疗方法,目前发病率逐年升高,严重威胁人类健康。现有数据显示,血吸虫感染或注射血吸虫相关蛋白可能保护或减轻机体免受自身免疫性疾病的损害。研究学者已经建立相应的小鼠自身免疫疾病模型,证实了注射血吸虫蛋白具有诱导宿主Th2免疫偏移,下调Th17反应,并诱导旁路途经活化的巨噬细胞,从而减轻自身免疫性疾病,具有肯定的治疗效果。在这篇综述中,我们总结了血吸虫感染及血吸虫相关蛋白与减轻Th1介导的自身免疫性疾病之间的关系,力争明确其潜在的免疫保护机制。
Autoimmune diseases (ADs) are characterized by chronic injury and dysfunction in a specific target organ or multiple organ systems. There is a lack of effective clinical treatment methods. The current incidence is increasing year by year, which seriously threatens human health. Available data show that schistosome infection or injection of schistosome-associated proteins may protect or reduce the body from autoimmune diseases. Researchers have established a model of autoimmune disease in mice and confirmed that the injected Schistosoma japonicum protein has the ability to induce host Th2 immune offset, down-regulate Th17 response, and induce bypassing of activated macrophages, thereby alleviating autoimmune diseases with positive Therapeutic effect. In this review, we summarize the relationship between schistosome infection and schistosome-associated proteins and the mitigation of Th1-mediated autoimmune diseases in an attempt to clarify their underlying mechanisms for immune protection.