论文部分内容阅读
目的：探讨氯化血红素（ｈｅｍｉｎ）治疗贫血的疗效及其口服的毒性反应．方法：用自制的ｈｅｍｉｎ按每日９３，１６８，３００ｍｇ·ｋｇ－１治疗失血性贫血大鼠，并与葡萄糖酸亚铁（ＦＧ３００ｍｇ·ｋｇ－１·ｄ－１）治疗组及单纯给水组比较．２４ｈ内对２０只小鼠予ｈｅｍｉｎ６ｇ·ｋｇ－１灌胃以观察小鼠的急性毒性反应．对８０只大鼠连续３个月分别予ｈｅｍｉｎ０６５，１３，２６ｇ·ｋｇ－１·ｄ－１灌胃，观察大鼠的长期毒性反应．结果：治疗后各组Ｈｂ变化依次为６６→１２１，７１→１４１，６６→１４８，６９→１４１，６７→１１２ｇ·Ｌ－１；观察７ｄ未见小鼠急性毒性反应；用药３个月后对８０只大鼠进行血象检查、肝肾功能检查及１５个脏器组织活检均未见明显异常．结论：Ｈｅｍｉｎ抗贫血疗效优于ＦＧ；口服无任何毒副作用．
Objective: To investigate the curative effect of hemin on anemia and oral toxicity. Methods: Hemolytic anemia rats were treated with homemade hemin at the daily doses of 93,168 and 300 mg · kg-1, and compared with those treated with FG 300 mg · kg-1 · d-1 and water alone. Twenty mice were treated with hemin 6 g · kg -1 intragastrically in order to observe the acute toxicity of mice. 80 rats for 3 consecutive months were hemin0 65,1 3,2 6g · kg-1 · d-1 gavage, observed long-term toxicity in rats. Results: After treatment, the Hb changes in each group followed by 66 → 121,71 → 141,66 → 148,69 → 141,67 → 112g · L-1; no acute toxicity was observed in 7 days; after 3 months 80 rats for blood test, liver and kidney function tests and 15 organs biopsy showed no significant abnormalities. Conclusion: Hemin has better anti-anemic effect than FG. There is no side-effect of oral administration.