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目的 :进一步探讨免疫功能改变在艾滋病相关的卡波西肉瘤 (AIDS- KS)发病中的作用。方法 :对 12例AIDS- KS,32例无卡波西肉瘤的 HIV感染者 (HIV- NKS)和 16例正常对照进行了研究 ,用 EL ISA对 8例 AIDS- KS,2 8例 HIV- NKS和 16例正常对照血清 (或血浆 )进行了 s Fas,β 2 -微球蛋白 (β 2 - MG) ,IL - 10 ,IL- 16 ,IL- 18,IL- 6和可溶性 IL - 4受体 (s IL- 4R)测定 ,对 12例 AIDS- KS,32例 HIV- NKS外周血淋巴细胞、淋巴细胞亚群及 CD38+CD8,HLA- DR+ CD8进行了分析。结果 :β 2 - MG,s IL- 4R水平在 HIV- NKS组明显高于正常对照组 ,IL- 16水平在HIV- NKS组明显低于正常对照组 ,IL - 18水平在 HIV- NKS组和 AIDS- KS组均明显高于正常对照组 ;CD3、CD4、CD8、NK、HLA- DR+ CD8在 AIDS- KS均低于 HIV- NKS,而 AIDS- KS组 CD19、CD38+ CD8高于 HIV- NKS组 ,但各组间差异无显著性。结论 :AIDS- KS和 HIV- NKS一样存在一定程度的免疫激活 ,但 AIDS- KS和 HIV- NKS间免疫状态无明显差异 ,提示免疫状态的差异可能不是艾滋病患者并发卡波西肉瘤的主要原因。
Objective: To further investigate the role of immune function changes in the pathogenesis of AIDS-related Kaposi’s sarcoma (AIDS-KS). Methods: Twelve AIDS-KS patients, 32 HIV-NKS patients without Kaposi’s sarcoma, and 16 normal controls were studied. Eight patients with AIDS-KS, 28 HIV-NKS S, β 2 - microglobulin (β 2 - MG), IL - 10, IL - 16, IL - 18, IL - 6 and soluble IL - 4 receptor were measured in 16 normal control serum and plasma (sIL-4R), 12 cases of AIDS-KS, 32 cases of HIV-NKS peripheral blood lymphocytes, lymphocyte subsets and CD38 + CD8, HLA-DR + CD8 were analyzed. Results: The levels of β 2 - MG, s IL - 4R in HIV - NKS group were significantly higher than those in normal control group. The levels of IL - 16 in HIV - NKS group were significantly lower than those in normal control group. The levels of IL - AIDS-KS group were significantly higher than the normal control group; CD3, CD4, CD8, NK, HLA-DR CD8 in AIDS-KS were lower than HIV-NKS, AIDS-KS group CD19, CD38 CD8 higher than the HIV-NKS group , But no significant difference between the groups. Conclusion: AIDS-KS and HIV-NKS have the same degree of immune activation, but there is no significant difference in immune status between AIDS-KS and HIV-NKS, suggesting that the difference in immune status may not be the main reason for AIDS-related Kaposi’s sarcoma.