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目的 探讨急性一氧化碳中毒后迟发性脑病 (DEACMP)患者脑神经元的损伤。方法 应用酶联免疫分析法测定 4 0例DEACMP患者和 30例对照组血清及脑脊液 (CSF)神经元特异性烯醇化酶 (NSE)浓度。应用直线相关分析方法分析NSE浓度与病情严重程度以及预后的关系。结果 对照组血清和CSFNSE浓度分别为 (8.0 1± 6 .78)ug/L和 (6 .74± 5 .31)ug/L。观察组血清和CSFNSE浓度分别为 (15 .2 1± 6 .78)ug/L和 (13.6 1± 5 .2 7)ug/L。观察组与对照组之间存在明显的统计学差异 (P <0 .0 1)。NSE浓度与病情严重程度及预后之间存在相关性。结论 DEACMP患者血清及CSFNSE浓度明显增高 ,NSE浓度的高低可作为脑神经元损伤的量化指标 ,也可能是判断病情、估计预后的重要参数。
Objective To investigate the neuronal damage in patients with delayed encephalopathy (DEACMP) after acute carbon monoxide poisoning. Methods Serum and cerebrospinal fluid (CSF) neuron specific enolase (NSE) concentrations were determined in 40 patients with DEACMP and 30 controls by enzyme-linked immunosorbent assay. Linear correlation analysis was used to analyze the relationship between NSE concentration and disease severity and prognosis. Results The serum and CSF NSE concentrations in the control group were (8.01 ± 6.78) ug / L and (6.74 ± 5.31) ug / L, respectively. The serum and CSF NSE concentrations in the observation group were (15.21 ± 6.78) ug / L and (13.6 1 ± 5.27) ug / L, respectively. There was a significant difference between observation group and control group (P <0.01). There is a correlation between the concentration of NSE and the severity of the disease and its prognosis. Conclusions Serum and CSF NSE levels are significantly increased in patients with DEACMP. The level of NSE can be used as a quantitative indicator of neuronal damage, and may be an important parameter for judging the prognosis of patients with DEACMP.