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目的 :探讨不均等分割与常规分割放射治疗食管癌 12 0例疗效。方法 :( 1)不均等放疗组 60例 ,周一上午胸前垂直野( A) 2 5 0 c Gy间隔 6h,胸背垂直野 ( B) 2 5 0 c Gy。周二～五 ,胸背二侧野 ( C、D)轮照 ,每天各 140 c Gy/次 ,周六周日休息两天后重复上周治疗。肿瘤量 5 3 0 0 c Gy/3 0次· 3 5天。改缩胸前侧野 ( E、F野 )照射方法同前 ,照射剂量 10 60 c Gy/6次。总肿瘤量为 63 60 c Gy/3 6次· 42天。 ( 2 )常规分割放疗组 60例 ,每周 5次 ,每日轮照一野 ,每野 2 0 0 c Gy,休息两天后依次轮照 ,肿瘤总量 660 0 c Gy/3 3次· 45天。结果 :1、2年生存率 :不均等组 71.7%及 5 0 .0 %,常规组 46.7%及 3 5 .0 %,两组比较差异有显著性 ( P<0 .0 5 )。近期疗效好转率 :不均等组95 .0 %,常规组 73 .3 %,两组比较差异有显著性 ( P<0 .0 5 ) ,临床症状改善率 :不均等组 88.4%,常规组 71.7%,两组比较差异有显著性 ( P<0 .0 1)。结论 :不均等分割放射治疗能显著提高食管癌 1、2年的生存率 ,病人能顺利完成疗程。
Objective : To investigate the effect of unequal segmentation and conventional segmentation radiotherapy for esophageal cancer in 120 cases. Methods: (1) Inequality radiotherapy group 60 cases, Monday morning chest vertical field (A) 2 5 0 c Gy interval 6h, thoracodorsal vertical field (B) 2 5 0 c Gy. From Tuesday to Friday, the thoracodorsal field (C, D) was photographed with 140 c Gy/day, and the treatment was repeated last week after two days of rest on Saturday and Sunday. Tumor volume 5 3 0 0 c Gy/3 0 3 5 days. Change the front side of the chest (E, F wild) irradiation method with the former, irradiation dose 10 60 c Gy / 6 times. The total tumor volume was 63 60 c Gy/3 6 times 42 days. (2) 60 cases of conventional segmentation radiotherapy group, 5 times a week, daily rotation of a field, each field 200 g Gy, followed by two days after the rest of the rotation, tumor total 660 0 c Gy/3 3 45 day. Results: The 1-year and 2-year survival rates were 71.7% and 50% in the unequal group and 46.7% and 35.0% in the routine group. There was a significant difference between the two groups (P<0.05). The improvement rate of curative effect in the short term was 95.0 % in the unequal group and 73.3 % in the routine group. There was a significant difference between the two groups (P 0.05). The improvement rate of clinical symptoms was 88.4% in the unequal group and 71.7 in the regular group. %, the difference between the two groups was significant (P < 0.01). Conclusion : Unequally divided radiotherapy can significantly improve the survival rate of esophageal cancer for 1 or 2 years. The patient can successfully complete the course of treatment.