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肝细胞癌(hepatocellular carcinoma,HCC)是世界上最常见的恶性肿瘤之一。流行病学研究显示,多种遗传学因素与环境致病因素均可导致HCC的发生,并有地域的差异性。例如在日本及欧美国家,70%以上的HCC发生与慢性丙型肝炎病毒(hepatitisCvirus,HCV)感染和高摄入酒精有关;在我国,特别是广西地区,大约80%以上的HCC与该地区慢性乙型肝炎病毒(hepatitisB virus,HBV)的高感染率以及黄曲霉毒素B1(aflatoxin B1,AFB1)的高暴露密切相关。HCC的发生、发展是多因素综合作用的结果,包括多种癌基因、抑癌基因、生长因子及其受体等共同参与,
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Epidemiological studies have shown that a variety of genetic factors and environmental risk factors can lead to the occurrence of HCC, and regional differences. For example, in Japan and Europe and the United States, more than 70% of HCC occurs with chronic hepatitis C virus (HCV) infection and high intake of alcohol; in our country, especially Guangxi, about 80% of HCC and the region of chronic The high infection rate of hepatitis B virus (HBV) and the high exposure of aflatoxin B1 (AFB1) are closely related. The occurrence and development of HCC are the result of multifactorial combination of multiple oncogenes, tumor suppressor genes, growth factors and their receptors,