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目的探讨恶性肿瘤患者手术前后血清血管内皮生长因子(VEGF)和肝细胞生长因子(HGF)水平变化及其临床价值。方法应用酶联免疫吸附(ELISA)法测定49例恶性肿瘤患者血清VEGF和HGF水平在术前及术后1个月的变化,并测定35例对照组血清VEGF和HGF水平。结果①对照组血清中有微量的血清VEGF和HGF,恶性肿瘤患者术前血清VEGF和HGF水平均显著高于正常对照组(P<0.01);②恶性肿瘤患者术前血清VEGF和HGF水平与其有无转移有关,有转移组血清VEGF和HGF水平显著高于无转移组(P<0.01);③恶性肿瘤患者术后1个月血清VEGF和HGF水平较术前均显著降低(P<0.01);④恶性肿瘤患者血清VEGF与HGF呈显著正相关(r=0.7906,P<0.01)。结论 VEGF和HGF在恶性肿瘤的发生发展中具有重要作用,血清VEGF和HGF水平增高在胰腺癌中预示了一种更具有侵袭性的生物学行为。
Objective To investigate the changes of serum vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with malignant tumor before and after operation and their clinical value. Methods Serum levels of VEGF and HGF in 49 patients with malignant tumor were detected by enzyme-linked immunosorbent assay (ELISA) before and one month after operation. The serum levels of VEGF and HGF in 35 patients were determined. Results ① Serum levels of VEGF and HGF in the control group were significantly higher than those in the normal control group (P <0.01); ② The serum levels of VEGF and HGF in patients with malignant tumor were significantly higher than those in the control group The levels of serum VEGF and HGF in patients with metastasis were significantly higher than those without metastasis (P <0.01). The levels of serum VEGF and HGF in patients with malignant tumor at one month after operation were significantly lower than those before operation (P <0.01). Serum VEGF and HGF in patients with malignant tumors were significantly and positively correlated (r = 0.7906, P <0.01). Conclusions VEGF and HGF play an important role in the development of malignant tumors. Increased levels of serum VEGF and HGF predict a more aggressive biological behavior in pancreatic cancer.