论文部分内容阅读
目的研究ＣＴ引导立体定向放射性核素内放射治疗颅咽管瘤的有效性和安全性。方法采用ＣＴ引导立体定向技术对３００例颅咽管瘤进行了３８５次瘤内置入核素内放疗，并进行了随访观察。其中男１８０例，女１２０例，平均年龄３０．５岁。全部病例均有视路受损症状。ＣＴ或ＭＲＩ检查囊性肿瘤１７５例，实体性肿瘤４０例，实体与囊腔并存８５例。结果无手术死亡及严重并发症。术后２５０例随访６个月至８年，平均４年：肿瘤消失１８０例（７２％）；肿瘤显著缩小（＞８０％）３０例（１２％）；肿瘤缩小５０％左右２０例（８％）；肿瘤增大（主要为实体性）１６例（６．４％）；死亡４例（１．６％）。结论立体定向瘤内放射性核素间质内照射是治疗颅咽管瘤的一种有效方法；纯Ｂｅｔａ射线源Ｐ－３２和Ｙ－９０其穿透能力短易于运送与防护是理想的放射源；囊壁的照射剂量以２００－２５０Ｇｙ为好。
Objective To study the effectiveness and safety of CT guided stereotactic radionuclide radiation therapy for craniopharyngioma. Methods Thirty - five cases of craniopharyngiomas were treated by CT - guided stereotactic technique with radionuclide radiotherapy and were followed up. There were 180 males and 120 females, with an average age of 30.5 years. All cases have visual impairment symptoms. There were 175 cases of cystic tumors by CT or MRI, 40 cases of solid tumors and 85 cases of cysts and cysts. Results No operative deaths and serious complications. 250 cases were followed up for 6 months to 8 years with an average of 4 years: 180 cases (72%) disappeared in the tumor, 30 (12%) tumors were significantly reduced (> 80%) and 20 cases (8% ); Tumor growth (mainly solid) in 16 cases (6.4%); death in 4 cases (1.6%). Conclusion Stereotactic radionuclide interstitial irradiation is an effective method for the treatment of craniopharyngiomas. The pure Beta ray source P-32 and Y-90 have the short penetrating ability and are easy to transport and protect. The wall of the radiation dose to 200-250Gy as well.