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目的探讨心肌做功指数(myocardial performance index,MPI,又称Tei指数)在评价蒽环类药物(anthracy-cline,ATC)对肿瘤患者心功能早期损害方面的临床应用价值。方法测定并比较50例肿瘤患者ATC化疗前和化疗后6个月常规超声心动图参数及Tei指数参数。结果Tei指数各相关参数显示ATC化疗后左、右心室等容舒张时间(IRT、IRT′)较化疗前明显延长(P<0.05);左、右心室等容收缩时间(ICT、ICT′),左室及右室射血时间(ET、ET′)较化疗前无显著性差异,但左、右心室Tei指数较化疗前有显著性增加(P<0.05)。左室射血分数(LVEF)在化疗前后无显著性差异,仅14例(28%)患者化疗后出现常规左室舒张功能指标异常,其中4例(8%)同时并发右心室舒张功能指标异常。结论Tei指数能更早、更敏感地评价ATC对肿瘤患者心脏功能损害。
Objective To investigate the clinical value of myocardial performance index (MPI), which is also called Tei index, in the evaluation of anthracycline (ATC) in early stage of cardiac function in patients with cancer. Methods The routine echocardiographic parameters and Tei index parameters of 50 patients with cancer before and after 6 months of chemotherapy were determined and compared. Results The related parameters of Tei index showed that the left and right ventricular isovolumic relaxation time (IRT, IRT ’) were significantly longer than those before chemotherapy (P <0.05) Left ventricular and right ventricular ejection time (ET, ET ’) than before chemotherapy no significant difference, but left and right ventricular Tei index than before chemotherapy significantly increased (P <0.05). Left ventricular ejection fraction (LVEF) had no significant difference before and after chemotherapy, only 14 patients (28%) had abnormal left ventricular diastolic function after chemotherapy, and 4 of them (8%) had abnormal right ventricular diastolic function . Conclusions The Tei index can evaluate cardiac function impairment in cancer patients earlier and more sensitively.