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目的探讨产前诊断技术对出生缺陷疾病诊断的临床意义,并对不同的畸形病种进行分析统计,为提高临床医生对缺陷胎儿产前诊断提供依据。方法通过孕期产科B超、产前筛查、染色体病产前诊断方法进行产前检查,并对长沙市妇幼保健院产前诊断中心近四年产前诊断资料进行分析。结果本院产前诊断中心近四年来对21170例孕妇通过产科彩超、产前筛查、染色体病产前诊断等技术共诊断并引产缺陷胎儿326例,产前诊断缺陷胎儿引产率为1.54%,缺陷种类按发病频率前三位依次为神经系统畸形,心血管系统畸形、泌尿系统畸形。结论通过产前超声检查、产前筛查技术、羊水染色体检查,能有效降低先天畸形患儿的出生,但仍存在一定的局限性。
Objective To investigate the clinical significance of prenatal diagnosis in the diagnosis of birth defects and to analyze and analyze the different deformities so as to provide evidences for improving prenatal diagnosis of defective fetuses. Methods Prenatal examination was conducted through prenatal diagnosis of obstetric B-prenatal screening, prenatal screening and chromosomal diseases. Prenatal diagnosis data of prenatal diagnosis center of Changsha MCH hospital were analyzed in the past four years. Results The prenatal diagnosis center of our hospital in the past four years, 21,170 cases of pregnant women through obstetric ultrasound, prenatal screening, chromosomal disease prenatal diagnosis and other techniques were diagnosed and induced abortion fetus 326 cases of fetuses, prenatal diagnosis of defective fetus fetus rate was 1.54% Defects according to the frequency of onset of the top three were nervous system deformity, cardiovascular system deformity, urinary system deformity. Conclusion Prenatal ultrasound, prenatal screening, amniotic fluid chromosome examination can effectively reduce the birth of children with congenital malformations, but there are still some limitations.