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本实验用离体肌鼠左房肌标本观察了青藤碱对异丙肾上腺素,氯化钙及组胺的剂量—效应关系的影响,青藤碱可使离体豚鼠左房的异丙肾上腺素剂量—效应曲线非平行右移,并降低最大反应值,pD′_2值为3.56±0.12,不同于β—受体阻断剂心得安。对氯化钙剂量—效应曲线的影响与钙通道阻滞剂戊脉安相似,表现为曲线非平行右移,最大反应降低,PD′_2值分别为3.43±0.11,6.13±0.16。对组胺剂量—效应曲线的影响与H_2—受体阻断剂甲氰咪胍不同,青藤碱呈非竞争性拮抗,pD′_2值为3.57±0.13。提示青藤碱的负性肌力作用可能在于阻滞钙通道,而不是竞争性阻断β—受体和H_2—受体。
In this study, we observed the effect of sinomenine on the dose-response relationship of isoproterenol, calcium chloride and histamine in left atrial muscle of isolated muscular rats. Sinomenine could induce the release of isoproterenol The prime dose-response curve shifted nonparallel to the right and decreased the maximal response, with a pD’_2 value of 3.56 ± 0.12, unlike propranolol. Calcium chloride dose-response curve and calcium channel blocker verapamil similar performance of the curve non-parallel shift to the right, the maximum response decreased, PD’_2 values were 3.43 ± 0.11,6.13 ± 0.16. Effect on histamine dose-response curve Unlike cimetidine, an H 2 -receptor blocker, sinomenine showed a non-competitive antagonism with a pD’_2 value of 3.57 ± 0.13. This suggests that the negative inotropic effects of sinomenine may lie in the block of calcium channels, rather than competitive blocking of the β-receptor and H 2 -receptors.