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目的:探讨早孕期间母体血清内脏素和脂联素浓度作为潜在指标预测妊娠期糖尿病(gestational diabetes mellitus,GDM)的价值。方法:选取100例最终发展为GDM的孕妇为病例组,100例没有发生GDM的孕妇为对照组,在妊娠11～13周使用ELISA试剂盒检测母体血清内脏素和脂联素浓度,并用Logistic回归分析内脏素和脂联素与妊娠期糖尿病发病的关系。结果:GDM组与非糖尿病组比较,母体血清内脏素浓度上升[(1.25±0.20)μg/L vs(0.81±0.11)μg/L,P<0.01],血清脂联素浓度下降[(7 631±758)μg/L vs(11 034±986)μg/L,P<0.01]。经Logistic回归分析,内脏素对GDM的比值比(OR)为3.06(95%CI:1.35～5.63),脂联素对GDM的OR值为0.318(95%CI:0.120～0.631)。结论:GDM组在妊娠11～13周血清内脏素浓度是上升的,脂联素浓度是下降的,这些生物指标联合检测能够为GDM提供有效的早期筛选。
Objective: To explore the value of maternal serum visfatin and adiponectin during pregnancy as a potential indicator of gestational diabetes mellitus (GDM). Methods: 100 pregnant women who eventually developed into GDM were selected as the case group and 100 pregnant women without GDM as the control group. The levels of serum visfatin and adiponectin in maternal serum were detected by ELISA kit at 11 to 13 weeks’ gestation. Logistic regression Analysis of the relationship between visceral and adiponectin and gestational diabetes mellitus. Results: Compared with non-diabetic group, the levels of serum visfatin increased in [(1.25 ± 0.20) μg / L vs (0.81 ± 0.11) μg / L, P <0.01] ± 758) μg / L vs (11 034 ± 986) μg / L, P <0.01]. Logistic regression analysis showed that the ratio of internal organs to GDM was 3.06 (95% CI: 1.35-5.63). The OR of adiponectin to GDM was 0.318 (95% CI: 0.120-0.631). CONCLUSION: Serum visfatin concentration is increased in GDM group from 11 to 13 weeks of gestation, and adiponectin concentration is decreased. Combined detection of these biomarkers can provide effective early screening for GDM.