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血管内表皮外凝血酶血栓调节素激活血浆C蛋白(PC)酶元是一个重要的内源性抗血栓形成机制。然尚不知激活的C蛋白(APC)是否在人体脑血管中产生,因只有有限的了解到血栓调节素在人体脑血管内皮的表达。本文证实颈动脉闭合引起脑特异PC激活的假说。 方法:研究对象为8个男性白人患者,年龄68±2岁,全部病例均有高血压病史,63％有糖尿病,半数有血高胆固醇症与近期抽烟史等中风危险因素。临床病史:冠心病,周围动脉闭塞病,无严重
Endothelial thrombin Thrombomodulin activates plasma protein C (PC) enzyme as an important endogenous antithrombotic mechanism. However, it is unknown whether activated protein C (APC) is produced in human cerebrovascular. Only a limited understanding of the expression of thrombomodulin in human cerebrovascular endothelium is available. This article demonstrates the hypothesis that carotid closure leads to brain-specific PC activation. Methods: The study population was 8 male white patients, aged 68 ± 2 years. All of the patients had history of hypertension, 63% had diabetes mellitus, half had hypercholesterolemia and recent smoking history. Clinical history: coronary heart disease, peripheral arterial occlusive disease, no serious