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目的了解玉环县海岛地区人群的血清甲状腺球蛋白抗体和过氧化物酶水平及探讨本地区自身免疫性甲状腺疾病多发的原因。方法 anti-TgAb、anti-TPOAb使用美国雅培公司生产的AXSYM全自动化学发光仪以及配套的进口试剂,方法采用微拉子酶免疫法MEIA进行定量测定血清甲状腺球蛋白抗体和甲状腺过氧化物酶浓度。结果甲状腺球蛋白抗体总的阳性率为32%,男性和女性的阳性率分别为28%、32%,男性和女性之间存在明显差异(P<0.05),各年龄组除41岁到50岁组与>61岁组存在显著性差异(P<0.05)外,其余均无显著性差异(P>0.05);甲状腺过氧化物酶抗体总的阳性率为35%,男性和女性的阳性率分别为34.6%、30.4%,男性和女性之间存在明显差异(P<0.05),各年龄组均无显著性差异(P>0.05)。结论本地区人群甲状腺自身抗体的高阳性率可能与当地高碘饮食,以及遗传易感性、生物因素、化学因素等环境因素有关。
Objective To understand the levels of serum thyroglobulin antibody and peroxidase in the population of Yuhuan County and to explore the reasons for the frequent occurrence of autoimmune thyroid diseases in the area. Methods anti-TgAb, anti-TPOAb using the United States Abbott AXSYM automated chemiluminescence instrument and imported reagents, the method using the microbe enzyme immunoassay MEIA quantitative determination of serum thyroglobulin antibody and thyroid peroxidase concentration . Results The total positive rate of thyroglobulin antibody was 32%. The positive rates of thyroglobulin antibody were 28% and 32% respectively, there was a significant difference between males and females (P <0.05) (P> 0.05). The total positive rate of thyroid peroxidase antibody was 35%, the positive rates of male and female were respectively (34.6%, 30.4%). There was a significant difference between males and females (P <0.05). There was no significant difference among all age groups (P> 0.05). Conclusion The high positive rate of thyroid autoantibodies in local population may be related to the local high iodine diet, and genetic factors such as genetic predisposition, biological factors and chemical factors.