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Objective: To observe the blocking effect of Huoxiang Zhengqi liquid (藿香正气水,HXZQL) on histamine release of basophils. Methods: The study was conducted using HXZQL to neutralize and block IgE and antagonize the effect of IL-3 induced enhancing histamine release of bosaphils. Concentration and percentage of histamine release of bosaphils were tested by the basophil histamine release test. Results: The HXZQL drug-serum had obvious inhibitive effect on degranulation of bosaphils induced by IgE antigen-antibody complex (P<0.05) and can successfully weaken the histamine release of basophils stimulated by IL-3. When compared with those in the untreated group, it showed P<0.01. Conclusion: HXZQL drug-serum may neutralize and block IgE and has inhibitive effects on degranulation of cells when resensitized by antigens. It can also block allergic response type Ⅰ by antagonizing the effect of IL-3 induced enhancing histamine release.