目的　探讨先天性心脏病( 先心病) 与弓形体( Toxoplasm a gondii, TOX) 感染的关系。　方法　对37 例先心病患儿及30 例健康儿童的外周血进行酶联免疫吸附试验( ELISA) 检测TOXlgG、TOXIg M ,对其中20例TOXIg G 阳性者的心肌组织采用PCR 检测TOXDNA。　结果　先心病组37 例,TOXIgG 阳性20 例,阳性率54 .1 % ;对照组30 例,TOXIgG 阳性7 例,阳性率23 % ,两组差异有显著性( χ2 = 5 .284 7 ,P< 0 .05) 。先心病组TOXIg M 阳性3 例,阳性率8 .1 % ;对照组TOXIg M 阳性2 例,阳性率6 .7 % ,两组差异无显著性( χ2 = 0 .059 6 ,P> 0 .05) 。20 例TOXIg G 阳性者心肌组织中TOXDNA 阳性7 例,阳性率35 % 。　结论　先心病与TOX 感染有关,先天性TOX 感染可能是先心病的致畸因子 Objective To investigate the relationship between congenital heart disease (CHD) and toxoplasma gondii (TOX) infection. Methods Thirty-seven children with CHD and 30 healthy children were detected by enzyme-linked immunosorbent assay (ELISA) for TOXlgG and TOXIg M, and 20 cases of TOXIgGpositive myocardium were detected by PCR Detection of TOX DNA. Results 37 cases of congenital heart disease, TOX IgG positive in 20 cases, the positive rate of 54.1%; control group of 30 cases, TOX IgG positive in 7 cases, the positive rate of 23%, the difference between the two groups was significant (χ2 = 5 .284 7, P <0 .05). There were 3 positive cases of TOXIg M in CHD group, the positive rate was 8.1%; in the control group, 2 cases were positive for TOXIg M, the positive rate was 6.7%, there was no significant difference between the two groups (χ2 = 0.059 6, P > 0 .05). TOX  Ig G positive in 20 cases of myocardial tissue TOX  DNA positive in 7 cases, the positive rate of 35%. Conclusions Congenital heart disease is associated with TOX infection. Congenital TOX infection may be a teratogenic factor of congenital heart disease