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目的:探索气温突变对高血压大鼠心梗发病及心肌损害的影响。方法:给予肾动脉半结扎大鼠一次维生素D370 U/kg体重腹腔注射,22℃环境下饲以高脂饲料。10周后随机分为S、J和D三组,S组予以30分钟内升温至40℃处理,J组予以30分钟内降温至4℃的处理,D组为对照组。结果:S组大鼠急性心梗发病率为59.09%,J组大鼠发病率为26.32%,D组发病率为28.57%,S组大鼠以及J组大鼠血清肌钙蛋白、肌酸激酶、谷草转氨酶、肌酸激酶同工酶、乳酸脱氢酶含量(P<0.05)均明显高于D组大鼠,S组与D组大鼠肌钙蛋白等含量(P>0.1)无显著差异。结论:气温骤升、骤降均能加重造成心肌损害,但夏季气温骤升所造成的急性心梗发病率高于气温的骤降。
Objective: To explore the effect of temperature mutation on the incidence of myocardial infarction and myocardial damage in hypertensive rats. Methods: The rats with renal artery ligation were given vitamin D370 U / kg body weight intraperitoneally and fed with high fat diet at 22 ℃. After 10 weeks, the mice were randomly divided into three groups: S, J and D. S group was warmed to 40 ℃ in 30 minutes, J group was cooled to 4 ℃ in 30 minutes, and D group was control group. Results: The incidence of acute myocardial infarction was 59.09% in group S, 26.32% in group J, and 28.57% in group D. Serum cardiac troponin, creatine kinase , Aspartate aminotransferase, creatine kinase isoenzyme and lactate dehydrogenase (P <0.05) were significantly higher in group D than in group D, and there was no significant difference in the content of troponin among groups S and D . Conclusion: The sudden increase in temperature may cause myocardial damage. However, the incidence of acute myocardial infarction caused by the sudden warming in summer is higher than the sudden drop in temperature.