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目的探讨甲氨蝶呤(MTX)与环孢素 A(CsA)联合治疗类风湿关节炎(RA)的疗效。方法于2002年6月至2005年6月将广东省遂溪县人民医院118例类风湿性关节炎患者随机分为联合治疗组61例,应用每周 MTX 15 mg 和 CsA 3 mg/(kg·d)联合治疗,MTX 组57例,应用 MTX 每周15 mg 治疗,观察治疗后患者的临床表现及化验指标改善情况。结果与治疗前相比,两组 RA 患者晨僵时间、关节压痛指数和肿胀指数、握力均有明显改善(P<0.01)。MTX+CsA 治疗组的显效率较 MTX 组高(P<0.05)。结论应用 MTX与 CsA 联合治疗具有协同作用,疗效确切,是一种很好的治疗 RA 的方案
Objective To investigate the effect of methotrexate (MTX) combined with cyclosporin A (CsA) on rheumatoid arthritis (RA). Methods From June 2002 to June 2005, 118 patients with rheumatoid arthritis in Suixi People ’s Hospital of Guangdong Province were randomly divided into a combined treatment group of 61 patients. MTX 15 mg and CsA 3 mg / (kg · d) Combination therapy, MTX group 57 cases, the application of MTX 15 mg per week treatment to observe the clinical manifestations of patients after treatment and improvement of laboratory indicators. Results Compared with those before treatment, morning stiffness time, joint tenderness index, swelling index and grip strength of RA patients in both groups were significantly improved (P <0.01). The markedly effective rate of MTX + CsA group was higher than that of MTX group (P <0.05). Conclusions The combination of MTX and CsA has a synergistic effect and a definite curative effect, which is a good treatment for RA